Are we asking the wrong questions? 🔬 Not a great difference between the 2 classes In several cases the disease keeps progressing 🧨 ✅ Waiting for amyloid removers 🔍 Long & winding road to the understanding of amyloidosis pathophysiology 🤔 Fibrosis & collagen production significant part of the process ❓ Why someone develops wild-type ATTR ( or SSA) & others...

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17
Feb

Blog | European Journal of Heart Failure

🔥 Beta_blockers in HFmrEF & HFpEF >16000 pts

✅ Association with ⬇️ CV ☠️ & HHF 🏥 in both groups ✳️ Be careful to chronotropic incompetence

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10
Feb

Blog | European Journal of Heart Failure

🔥 FAIR_HF2 : High dose IV FerricCarboxymaltose in iron deficiency & HFrEF to reduce morbidity & mortality

🍀 Rationale & Design

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03
Feb

Blog | European Journal of Heart Failure

🔥 🗞️ CANVAS & CREDENCE pooled analysis

Another proof of diuretic effect of SGLT2i

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27
Jan

Blog | European Journal of Heart Failure

🔥 FIDELITY subanalysis: Finerenone efficacy & Safety in CKD & T2DM, by diuretic use ~ 13.000 pts

No difference with or without diuretics about: Cardiovascular Death ☠️ + HF hospitalization 🏥Kidney outcomes 👂🏻

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20
Jan

Blog | European Journal of Heart Failure

🔥 SUGAR_DM_HF: CardiovascularMagneticResonance estimated Pulmonary CapillaryWedge Pressure & congestion markers, & effect of empagliflozin in HFrEF in pre_diabets & T2DM

⚡️ A new tool of CMR that can provide another evolution for multimodality imaging in HeartFailure

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13
Jan

Blog | European Journal of Heart Failure

HappyNewYear Linkedin CardioVascularCommunity by the HeartFailureUniversalAcademy. HFUA

Let’s start 2025 with a hot HeartFailure topic 🔥 Prediction of HF Events in DCM & HFmrEF using multiparametric CMR

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06
Jan

Blog | European Journal of Heart Failure

🔥 EVOLUTION : Observational study for multiparametric assessment of cardiac congestion in outpatient worsening HF (WHF)

Role of NTproBNP , TnHS , CystatinC

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03
Jan

Blog | European Journal of Heart Failure

🔥 Machine learning approach to identify phenotypes in patients with ischaemic HFrEF

HFUA HeartFailureUniversalAcademy It will be the future of phenotyping?

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17
Dec

Blog | European Journal of Heart Failure

🔥Outpatient WorseningHF & mortality in transthyretin cardiomyopathy

👉Oral diuretic intensification (ODI) predicts mortality ☠️ as HeartFailure Hospitalizations 🏥 👉 This in ATTR_CMP on treatment with tafamidis

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09
Dec

Blog | European Journal of Internal Medicine

🔥 Our observational study based on data of Regione Lombardia on more than 10 millions people showed a significant association between HeartFailure & Non_Cardiac_Comorbidites

A mean of 42 months of follow-up (2015-2019) ✅ More comorbidities associated with All_cause_death☠️ and ⬆️ rate of re-hospitalizations 🏥 ✅ The higher the n^ of comorbidities the longer the length of hospitalization 🚹🚺 Same data for both sexes ❗️ HF pts with 4 or more non cardiac comorbidities had a mean length of hospitalization of 45 days

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08
Dec

Blog | Roche

Il cuore è un organo endocrino che produce i peptidi natriuretici in risposta allo stress di parete che si genera nello scompenso cardiaco.

Il cuore è un organo endocrino che produce i peptidi natriuretici in risposta allo stress di parete che si genera nello scompenso cardiaco. L’ormone principale con effetti sistemici è il BNP, che viene prodotto come pro-ormone e poi scisso porzione attiva BNP e in quella non attiva NTproBNP. Il sistema dei peptidinatriuretici è il principale sistema neuro-ormonale che antagonizza gli...

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07
Dec

Blog | European Journal of Heart Failure

🔥DREAM_HF : Mesenchymal precursor cells ⬇️ ☠️ & major morbidity in ischemic HeartFailure with inflammation

🍀 A new hope beyond traditional pharmacological & devices therapy

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02
Dec

Blog | European Journal of Heart Failure

🔥 Gene 🧬 therapy in HeartFailure : HFA , European Society of Cardiology Council on CV genomics & WG Myocardial & Pericardial Diseases Scientific Statement

⚡️ State of art and future perspectives📕 Amyloidosis new therapies📘📙📗 Dilated, Hypertrophic,Restrictive and Arrhythmogenic Cardiomyopathies🧀 Hypercolesterolemia

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25
Nov

Blog | European Journal of Heart Failure

🔥 Water & Salt Balance in HF

👉 Not only sodium & salt 🧂 , but the majority is water 💧

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17
Nov

Blog | European Journal of Heart Failure

🔥 Cardiovascular toxicities of immunotherapy for cancer 💉 ☠️

👉 Incidence, Pathophysiology & Management of AdverseEvent by HFA & CardioOncology Council European Society of Cardiology

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11
Nov

Blog | Roche

Lo Scompenso Cardiaco colpisce più di 1 milione di persone in Italia, è la 1ª causa di ospedalizzazione al mondo ed è gravato da un alto tasso di mortalità – più alto di molti cancri – e di re-ospedalizzazione. ☠️ 🏥

I sintomi sono spesso aspecifici e in 1 un paziente su 3 portano a diagnosi errate. In generale lo Scompenso Cardiaco rimane largamente sottodiagnosticato, infatti circa l’80% dei pazienti riceve la diagnosi a seguito di un ricovero per Scompenso Cardiaco Acuto. 🚨 Questo espone i pazienti ad un rischio incrementale di morte del 28% rispetto ad un paziente che riceve...

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06
Nov

Blog | European Journal of Heart Failure

🔥 VICTOR trial design : Vericiguat in Chronic HFrEF

Will be vericiguat ready to be the 5th pharmacological pillar in HFrEF ? HFUA HeartFailureUniversalAcademy

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04
Nov

Blog | European Journal of Heart Failure

🔥 The 25in25 initiative : A novel project to reduce HF ☠️ 25% in the next 25 y

HFprevalence is still alarmingly raising 🚨 Detect the undetected & treat it 🍀 HFUA

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28
Oct

Blog | European Journal of Heart Failure

🔥 Microvascular obstruction (MVO) in amyloidosis

MVO is associated with an ⬆️ risk of ☠️ in AL but not in ATTR ✅This reflects the intrinsic differences between these 2 forms of CA 💀 The toxic effect of light chain amyloidosis. AL . One of the cultural legacies of Prof Rapezzi💡 🙏

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23
Oct

Blog | European Journal of Heart Failure

🔥 FOREST_HCM : Aficamtem in Non-Obstructive HCM (HNOCM)

⬆️ Symptoms (NYHA) QoL (KCCQ) ⬇️ TnI & NTproBNP 🍀 Safe with mild ⬇️ of LVEF 💊 A new treatment for HNOCM is coming

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17
Oct

Blog | Minerva Cardiology Angiology

🔥 Our article dedicated to a new predictive score in extrasystolic arrhythmia : “EX-prognosis”

A beautiful idea of Olga Germanova Thanks to all the authors Giuseppe Biondi Zoccai Minerva Cardiology Angiology

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14
Oct

Blog | European Journal of Heart Failure

🔥 Diabetic myocardial disorder

A new statement of HFA & European Society of Cardiology WG on Myocardial & Pericardial Diseases A complex interplay in the CardioRenalMetabolic axis

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03
Oct

Blog | World Heart Day

World Heart Day

Cardiovascular Diseases are the 1st cause of ☠️ and HeartFailure is the 1st cause of hospitalization globally 🌍 ! Let’s fight them together ! Protect Heart ❤️ 🫀 Cardiovascular Diseases produced a cost only in the European Union and only for 2021 of 282 billions of euros 💶 🔥

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29
Sep

Blog | European Journal of Heart Failure

🔥 Association of Multiple Non HCM & outcomes in HCM

A new study on multiple mutations & poor outcomes in HCM 🧬 See our recent editorial “The Role of Multiple Mutations in HCM – A New Universe to discover 🔥 Multiple mutations in HCM are associated with End_Stage or Hypokinetic & Dilated evolution & with HF & arrhythmia development

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29
Sep

Blog | European Journal of Heart Failure

🔥 Aetiology & Clinical manifestations of NDLVC

🍀 Genetic a prevalent cause🔬 Myocarditis can uncover a genetic CMP🫀 NDLVC a starting disease phenotype

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23
Sep

Blog | European Journal of Heart Failure

🔥 HF risk assessment in HCM based on the H2FPEF score

Risk prediction in both HOCM & HNOCM HCM a cause not a “mimic” of HFpEF

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16
Sep

Blog | European Journal of Heart Failure

🔥 DECISION A new RCT on low dose digoxin in HF with LVEF < 50% both sinus rhythm & AF

Will be the last trial on the topic? Maybe we will obtain a final answer 🍀

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09
Sep

Blog | European Journal of Heart Failure

🔥 EXPAND: A real life study that confirms that the major driver of benefits of MitraClip in FMR & HFrEF

EXPAND a study that shows the same results of a fresh meta-analysis which included COAPT MITRA_FR & RESHAPE_HF2 > more than 800 pts With due differences among populations but for the same disease

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02
Sep

Blog | The new england journal of medicine

🔥❤️‍🔥FINEARTS_HF. FineHearts_HF

Finerenone confirmed a 16% RRR of CV ☠️ & Total HHF 🏥 A 2nd pillar for HFmrEF & HFpEF has just been built 🏛️ The need of new #2025 HFguidelines is now urgent!

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01
Sep

Blog | The new england journal of medicine

🔥 RESHAPE_HF2 NEJM Confirmed an important role of MitraClip in FMR & HFrEF

Similar effects of ARNI & SGLT2i RESHAPE_HF unveiled the grey part of the major benefit of MITRA_Clip is HHF Intermediate characteristics between MITRA_FR & COAPT & intermediate results between the 2 trials Drug & devices similar effects in HFrEF

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31
Aug

Blog | European Journal of Heart Failure

🔥 Implementation of GDMT for HeartFailure : Progress achieved, work ahead !

🏋️‍♀️ Still a lot of job to do to implement GDMT HF ☠️ still not significantly changed due to poor use of new therapies!

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26
Aug

Blog | European Journal of Heart Failure

🔥 NATRIUM_HF: Congestion & ⬆️ response to fluid/Na+ challenge in HFrEF after ARNI initiation

✅ Another proof of diuretic, natriuretic & Weight ⬇️ effect of ARNI

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18
Aug

Blog | European Journal of Heart Failure

🔥 Mechanisms of myocardial Reverse Remodeling: statement of European Society of Cardiology WG on myocardial function

From stressors, physiopathological models, therapeutic effects of drugs & devices & new treatments

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12
Aug

Blog | European Journal of Heart Failure

🔥 🗞️ VICTORIA echocardiography substudy:

⬇️ of biomarkers related to inflammation & cardiac metabolism (TNF_R1 & PRTN3) associated with reverse remodeling in HFrEF

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05
Aug

Blog | European Journal of Heart Failure

🔥 Updated Quality indicators for the care & outcomes of HeartFailure

Congrats to European Society of Cardiology hashtag#HFA Priv.-Doz. Dr. Amr Abdin for the eye-catching & instantly understable paper

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02
Aug

Blog | European Journal of Heart Failure

🔥 Change in 6mwt is an independent predictor of all-cause death in HFrEF

Discover the simple & easy to use 6mwt in HFrEF a predictor of ☠️ independent of: NYHA NTproBNP

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29
Jul

Blog | European Journal of Heart Failure

🔥 RESHAPE_HF2 High time to discover the grey part between the white (COAPT) & black side (MITRA_FR) of the moon 🌖

MitraClip in FMR & HFrEF 👉 Intermediate characteristics between COAPT & MITRA_FR 👉 ⬆️ % of ARNI & STLT2i use 🍀Results soon at ESCCongress

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22
Jul

Blog | European Journal of Heart Failure

🔥 Updated Quality indicators for the care & outcomes of HeartFailure

Congrats to European Society of Cardiology hashtag#HFA Priv.-Doz. Dr. Amr Abdin for the eye-catching & instantly understable paper

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18
Jul

Blog | European Journal of Heart Failure

🔥 FINEHEARTS_HF

🔍Discover the characteristics of HF population enrolled.The new kid on the block in HF & CardioRenalMetobolic area is coming soon at ESCCongress Finererone a new MRAHFUAEJHF 🔝 👉 36% HFmrEF👉 45% HFpEF (EF:50-60%)👉19% HFpEF>60%

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15
Jul

Blog | European Journal of Heart Failure

🍀A pleasure to collaborate again with the EJHF & European Society of Cardiology with Priv.-Doz. Dr. Amr Abdin & Han Naung Tun

Thank to Prof Böhm the Editor in Chief of the hashtag#EJHF for the invitation The best is yet to come 🍀

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12
Jul

Blog | European Journal of Heart Failure

🔥 Our new editorial on Cardiology 🍀

“The Role of Multiple Mutations in HCM – A New Universe to Discover:Proof of Guiltiness of the Genetic Burden in Worsening Hypertrophic Cardiomyopathy Natural History 🔬 🧬 Discover the role of multiple mutations & especially of calcium channels gene + sarcomeric mutations in HCM through our last editorial on Cardiology

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17
Jun